MEDU-27. ENHANCING SELUMETINIB-MEDIATED KILLING OF SHH MEDULLOBLASTOMA

Medulloblastoma (MB) is the most common primary malignant pediatric brain cancer with at least 5 distinct molecular subgroups. Of these subgroups, Sonic Hedgehog (SHH) MB exhibits extensive cellular heterogeneity, increased SHH signaling, and has an intermediate prognosis. Consequently, improved che...

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發表在:Neuro Oncol
Main Authors: Guppy, Brent, Liang, Lisa, Cheng, Stephen, Porter, Christopher, Werbowetski-Ogilvie, Tamra
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
主題:
Medulloblastoma
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477324/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.186
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