MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

Sonic hedgehog (SHH) medulloblastoma (MB(SHH)) accounts for approximately 25% of all MB diagnoses and is the predominant disease subgroup in infants and adults. Pediatric MB(SHH) is caused by an abnormal activation of the SHH pathway in granule cell progenitors (GNPs) in the developing cerebellum, b...

詳細記述

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書誌詳細
出版年:Neuro Oncol
主要な著者: Kutscher, Lena, Batora, Nadja, Okonechnikov, Konstantin, Clark, Jessica, Vouri, Mikaella, van Rijn, Sjoerd, Gearhart, Micah, Orr, Brent, Korshunov, Andrey, Kool, Marcel, Bardwell, Vivian, Pfister, Stefan M, Northcott, Paul A, Kawauchi, Daisuke
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2019
主題:
Medulloblastoma
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477224/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.180
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