MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

Sonic hedgehog (SHH) medulloblastoma (MB(SHH)) accounts for approximately 25% of all MB diagnoses and is the predominant disease subgroup in infants and adults. Pediatric MB(SHH) is caused by an abnormal activation of the SHH pathway in granule cell progenitors (GNPs) in the developing cerebellum, b...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Kutscher, Lena, Batora, Nadja, Okonechnikov, Konstantin, Clark, Jessica, Vouri, Mikaella, van Rijn, Sjoerd, Gearhart, Micah, Orr, Brent, Korshunov, Andrey, Kool, Marcel, Bardwell, Vivian, Pfister, Stefan M, Northcott, Paul A, Kawauchi, Daisuke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Medulloblastoma
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477224/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.180
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