MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

Sonic hedgehog (SHH) medulloblastoma (MB(SHH)) accounts for approximately 25% of all MB diagnoses and is the predominant disease subgroup in infants and adults. Pediatric MB(SHH) is caused by an abnormal activation of the SHH pathway in granule cell progenitors (GNPs) in the developing cerebellum, b...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Kutscher, Lena, Batora, Nadja, Okonechnikov, Konstantin, Clark, Jessica, Vouri, Mikaella, van Rijn, Sjoerd, Gearhart, Micah, Orr, Brent, Korshunov, Andrey, Kool, Marcel, Bardwell, Vivian, Pfister, Stefan M, Northcott, Paul A, Kawauchi, Daisuke
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Medulloblastoma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477224/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.180
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