MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

Sonic hedgehog (SHH) medulloblastoma (MB(SHH)) accounts for approximately 25% of all MB diagnoses and is the predominant disease subgroup in infants and adults. Pediatric MB(SHH) is caused by an abnormal activation of the SHH pathway in granule cell progenitors (GNPs) in the developing cerebellum, b...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Kutscher, Lena, Batora, Nadja, Okonechnikov, Konstantin, Clark, Jessica, Vouri, Mikaella, van Rijn, Sjoerd, Gearhart, Micah, Orr, Brent, Korshunov, Andrey, Kool, Marcel, Bardwell, Vivian, Pfister, Stefan M, Northcott, Paul A, Kawauchi, Daisuke
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Medulloblastoma
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477224/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.180
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