MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

Sonic hedgehog (SHH) medulloblastoma (MB(SHH)) accounts for approximately 25% of all MB diagnoses and is the predominant disease subgroup in infants and adults. Pediatric MB(SHH) is caused by an abnormal activation of the SHH pathway in granule cell progenitors (GNPs) in the developing cerebellum, b...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Kutscher, Lena, Batora, Nadja, Okonechnikov, Konstantin, Clark, Jessica, Vouri, Mikaella, van Rijn, Sjoerd, Gearhart, Micah, Orr, Brent, Korshunov, Andrey, Kool, Marcel, Bardwell, Vivian, Pfister, Stefan M, Northcott, Paul A, Kawauchi, Daisuke
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Medulloblastoma
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477224/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.180
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