Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation

Medulloblastoma is a malignant childhood brain tumor arising from the developing cerebellum. In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant activation of SHH signaling causes increased proliferation of granule neuron progenitors (GNPs), and predisposes these cells to tumorigenesis. A sec...

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Publicado en:Genes Dev
Main Authors: Kutscher, Lena M., Okonechnikov, Konstantin, Batora, Nadja V., Clark, Jessica, Silva, Patricia B.G., Vouri, Mikaella, van Rijn, Sjoerd, Sieber, Laura, Statz, Britta, Gearhart, Micah D., Shiraishi, Ryo, Mack, Norman, Orr, Brent A., Korshunov, Andrey, Gudenas, Brian L., Smith, Kyle S., Mercier, Audrey L., Ayrault, Olivier, Hoshino, Mikio, Kool, Marcel, von Hoff, Katja, Graf, Norbert, Fleischhack, Gudrun, Bardwell, Vivian J., Pfister, Stefan M., Northcott, Paul A., Kawauchi, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462063/
https://ncbi.nlm.nih.gov/pubmed/32820036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.337584.120
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