Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation

Medulloblastoma is a malignant childhood brain tumor arising from the developing cerebellum. In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant activation of SHH signaling causes increased proliferation of granule neuron progenitors (GNPs), and predisposes these cells to tumorigenesis. A sec...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Kutscher, Lena M., Okonechnikov, Konstantin, Batora, Nadja V., Clark, Jessica, Silva, Patricia B.G., Vouri, Mikaella, van Rijn, Sjoerd, Sieber, Laura, Statz, Britta, Gearhart, Micah D., Shiraishi, Ryo, Mack, Norman, Orr, Brent A., Korshunov, Andrey, Gudenas, Brian L., Smith, Kyle S., Mercier, Audrey L., Ayrault, Olivier, Hoshino, Mikio, Kool, Marcel, von Hoff, Katja, Graf, Norbert, Fleischhack, Gudrun, Bardwell, Vivian J., Pfister, Stefan M., Northcott, Paul A., Kawauchi, Daisuke
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462063/
https://ncbi.nlm.nih.gov/pubmed/32820036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.337584.120
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