MBRS-51. MUTATIONS IN BRPF1 FOUND IN SHH MEDULLOBLASTOMA PREVENT INTERACTION WITH TP53 AND LEADS TO RADIORESISTANCE IN VITRO

Medulloblastoma (MB) is one of the most common pediatric tumors in children. Among them, SHH subgroups of MB (MB(SHH)) is characterized by constitutive activation of SHH pathway. Somatic mutations in BRPF1, a chromatin modifier, is found in more than 5% of MB(SHH) and accounts for almost 20% of adul...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Vouri, Mikaela, Mercier, Audrey, da Silva, Patricia Benites Goncalves, Okonechnikov, Konstantin, Forget, Antoine, Yu, Hua, Chivet, Anais, Kool, Marcel, Pfister, Stefan, Ayrault, Olivier, Kawauchi, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Medulloblastoma (Research)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715508/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.558
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