MBRS-06. Gli3 INDUCES NEURONAL DIFFERENTIATION IN WNT- AND SHH- ACTIVATED MEDULLOBLASTOMA

BACKGROUND: We have previously investigated the expression of Gli3, a downstream target of the Sonic Hedgehog pathway, which main function is to suppress Gli1/2 in medulloblastomas. We found that Gli3 is associated with neuronal and glial differentiation in desmoplastic / nodular (D/N) type medullob...

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Vydáno v:Neuro Oncol
Hlavní autoři: Natsumeda, Manabu, Miyahara, Hiroaki, Yoshimura, Junichi, Tsukamoto, Yoshihiro, Oishi, Makoto, Wataya, Takafumi, Eberhart, Charles, Kakita, Akiyoshi, Fujii, Yukihiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Medulloblastoma (Research)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715217/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.526
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