MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas

Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack of O6-methyl-guanine-DNA methyltransferase (MGMT) promoter methylation...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Abe, Hideaki, Natsumeda, Manabu, Okada, Masayasu, Watanabe, Jun, Tsukamoto, Yoshihiro, Kanemaru, Yu, Yoshimura, Junichi, Oishi, Makoto, Hashizume, Rintaro, Kakita, Akiyoshi, Fujii, Yukihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985080/
https://ncbi.nlm.nih.gov/pubmed/32039031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01568
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