MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas

Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack of O6-methyl-guanine-DNA methyltransferase (MGMT) promoter methylation...

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Bibliografische gegevens
Gepubliceerd in:Front Oncol
Hoofdauteurs: Abe, Hideaki, Natsumeda, Manabu, Okada, Masayasu, Watanabe, Jun, Tsukamoto, Yoshihiro, Kanemaru, Yu, Yoshimura, Junichi, Oishi, Makoto, Hashizume, Rintaro, Kakita, Akiyoshi, Fujii, Yukihiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Oncology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985080/
https://ncbi.nlm.nih.gov/pubmed/32039031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01568
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