MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas

Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O(6)-methylguanine-DNA methyltransferase (MGM...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neurol Med Chir (Tokyo)
मुख्य लेखकों: ABE, Hideaki, NATSUMEDA, Manabu, KANEMARU, Yu, WATANABE, Jun, TSUKAMOTO, Yoshihiro, OKADA, Masayasu, YOSHIMURA, Junichi, OISHI, Makoto, FUJII, Yukihiko
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Japan Neurosurgical Society 2018
विषय:
Review Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048353/
https://ncbi.nlm.nih.gov/pubmed/29848907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2176/nmc.ra.2018-0044
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