MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas

Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O(6)-methylguanine-DNA methyltransferase (MGM...

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Bibliographic Details
Published in:Neurol Med Chir (Tokyo)
Main Authors: ABE, Hideaki, NATSUMEDA, Manabu, KANEMARU, Yu, WATANABE, Jun, TSUKAMOTO, Yoshihiro, OKADA, Masayasu, YOSHIMURA, Junichi, OISHI, Makoto, FUJII, Yukihiko
Format: Artigo
Language:Inglês
Published: The Japan Neurosurgical Society 2018
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048353/
https://ncbi.nlm.nih.gov/pubmed/29848907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2176/nmc.ra.2018-0044
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