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MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O(6)-methylguanine-DNA methyltransferase (MGM...
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| Publié dans: | Neurol Med Chir (Tokyo) |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Japan Neurosurgical Society
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6048353/ https://ncbi.nlm.nih.gov/pubmed/29848907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2176/nmc.ra.2018-0044 |
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