MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas

Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack of O6-methyl-guanine-DNA methyltransferase (MGMT) promoter methylation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Oncol
Egile Nagusiak: Abe, Hideaki, Natsumeda, Manabu, Okada, Masayasu, Watanabe, Jun, Tsukamoto, Yoshihiro, Kanemaru, Yu, Yoshimura, Junichi, Oishi, Makoto, Hashizume, Rintaro, Kakita, Akiyoshi, Fujii, Yukihiko
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Oncology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985080/
https://ncbi.nlm.nih.gov/pubmed/32039031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01568
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