MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas

Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack of O6-methyl-guanine-DNA methyltransferase (MGMT) promoter methylation...

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Bibliografiska uppgifter
I publikationen:Front Oncol
Huvudupphovsmän: Abe, Hideaki, Natsumeda, Manabu, Okada, Masayasu, Watanabe, Jun, Tsukamoto, Yoshihiro, Kanemaru, Yu, Yoshimura, Junichi, Oishi, Makoto, Hashizume, Rintaro, Kakita, Akiyoshi, Fujii, Yukihiko
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Oncology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985080/
https://ncbi.nlm.nih.gov/pubmed/32039031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01568
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