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MEDU-06. TARGETING MYC AND OTX2-DRIVEN TRANSCRIPTIONAL DEPENDENCIES OF GROUP 3 MEDULLOBLASTOMA THROUGH CDK7 INHIBITION
Medulloblastoma (MB) is the most frequent malignant childhood brain cancer and Group 3 MB (G3-MB) has the worst prognosis among the four consensus molecular subtypes. In G3-MB, MYC and OTX2 have been shown to be the oncogenic drivers and master transcriptional factors that tumor cells are highly add...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477377/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.166 |
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