MEDU-13. FUNCTIONAL CRISPR-CAS9 SCREEN IDENTIFIES DRUGGABLE DEPENDENCIES IN MYC-DRIVEN MEDULLOBLASTOMA

Myc-driven Medulloblastoma remains a major therapeutic challenge due to frequent metastasis and a poor 5-year survival rate. Myc overexpression results in transcriptional dysregulation, proliferation, and survival of malignant cells. However direct inhibition of Myc remains an obstacle to therapeuti...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Veo, Bethany, Fosmire, Susan, Wang, Dong, Madhavan, Krishna, Pierce, Angela, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Medulloblastoma
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477310/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.172
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