MBRS-65. FBXW7 ACTS A TUMOR SUPPRESSOR IN MYC-DRIVEN MEDULLOBLASTOMA BY CONTROLLING A FEED-FORWARD REGULATORY LOOP OF PLK1 AND MYC

Group 3 medulloblastoma (MB) is often accompanied by MYC amplification and has a higher rate of metastatic disease. So, it is critical to have more effective therapies for high MYC expressing sub-groups. Here we report that FBXW7, a substrate recognition component of the SKP1-CUL1-Fbox (SCF) E3 liga...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Madhavan, Krishna, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Medulloblastoma (Research)
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715689/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.569
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak