MBRS-65. FBXW7 ACTS A TUMOR SUPPRESSOR IN MYC-DRIVEN MEDULLOBLASTOMA BY CONTROLLING A FEED-FORWARD REGULATORY LOOP OF PLK1 AND MYC

Group 3 medulloblastoma (MB) is often accompanied by MYC amplification and has a higher rate of metastatic disease. So, it is critical to have more effective therapies for high MYC expressing sub-groups. Here we report that FBXW7, a substrate recognition component of the SKP1-CUL1-Fbox (SCF) E3 liga...

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Publicat a:Neuro Oncol
Autors principals: Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Madhavan, Krishna, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Medulloblastoma (Research)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715689/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.569
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