MBRS-65. FBXW7 ACTS A TUMOR SUPPRESSOR IN MYC-DRIVEN MEDULLOBLASTOMA BY CONTROLLING A FEED-FORWARD REGULATORY LOOP OF PLK1 AND MYC

Group 3 medulloblastoma (MB) is often accompanied by MYC amplification and has a higher rate of metastatic disease. So, it is critical to have more effective therapies for high MYC expressing sub-groups. Here we report that FBXW7, a substrate recognition component of the SKP1-CUL1-Fbox (SCF) E3 liga...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Madhavan, Krishna, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Medulloblastoma (Research)
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715689/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.569
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares