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CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists
The aberrant hedgehog (Hh) pathway plays important roles in multiple cancer types, therefore serving as a promising drug target. Current clinically available hedgehog-targeted drugs act mostly by antagonizing the upstream component smoothened; however, both primary and acquired resistance to FDA-app...
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| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6600918/ https://ncbi.nlm.nih.gov/pubmed/31182587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815780116 |
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