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Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

The Hedgehog signaling pathway plays an essential role in embryo development and adult tissue homeostasis, in regulating stem cells and is abnormally activated in many cancers. Given the importance of this signaling pathway, we developed a novel and versatile high-throughput, cell-based screening pl...

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Bibliografische gegevens
Hoofdauteurs: Wang, Jiangbo, Mook, Robert A., Lu, Jiuyi, Gooden, David M., Ribeiro, Anthony, Guo, Anchen, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501270/
https://ncbi.nlm.nih.gov/pubmed/23063522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.09.030
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