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Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
The Hedgehog signaling pathway plays an essential role in embryo development and adult tissue homeostasis, in regulating stem cells and is abnormally activated in many cancers. Given the importance of this signaling pathway, we developed a novel and versatile high-throughput, cell-based screening pl...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501270/ https://ncbi.nlm.nih.gov/pubmed/23063522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.09.030 |
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