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Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

The Hedgehog signaling pathway plays an essential role in embryo development and adult tissue homeostasis, in regulating stem cells and is abnormally activated in many cancers. Given the importance of this signaling pathway, we developed a novel and versatile high-throughput, cell-based screening pl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Wang, Jiangbo, Mook, Robert A., Lu, Jiuyi, Gooden, David M., Ribeiro, Anthony, Guo, Anchen, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501270/
https://ncbi.nlm.nih.gov/pubmed/23063522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.09.030
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