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Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

The Hedgehog signaling pathway plays an essential role in embryo development and adult tissue homeostasis, in regulating stem cells and is abnormally activated in many cancers. Given the importance of this signaling pathway, we developed a novel and versatile high-throughput, cell-based screening pl...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Jiangbo, Mook, Robert A., Lu, Jiuyi, Gooden, David M., Ribeiro, Anthony, Guo, Anchen, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501270/
https://ncbi.nlm.nih.gov/pubmed/23063522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.09.030
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