Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

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Hlavní autoři: Peluso, Marisa O., Campbell, Veronica T., Harari, Joseph A., Tibbitts, Thomas T., Proctor, Jennifer L., Whitebread, Nigel, Conley, James M., White, Kerry F., Kutok, Jeffery L., Read, Margaret A., McGovern, Karen, Faia, Kerrie L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946503/
https://ncbi.nlm.nih.gov/pubmed/24608250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090534
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