Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

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Main Authors: Peluso, Marisa O., Campbell, Veronica T., Harari, Joseph A., Tibbitts, Thomas T., Proctor, Jennifer L., Whitebread, Nigel, Conley, James M., White, Kerry F., Kutok, Jeffery L., Read, Margaret A., McGovern, Karen, Faia, Kerrie L.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946503/
https://ncbi.nlm.nih.gov/pubmed/24608250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090534
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