Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926

Conserved embryonic signaling pathways such as Hedgehog (Hh), Wingless and Notch have been implicated in the pathogenesis of several malignancies. Recent data suggests that Hh signaling plays a role in normal B-cell development, and we hypothesized that Hh signaling may be important in precursor B-c...

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Main Authors: Lin, Tara L., Wang, Qiuju H., Brown, Patrick, Peacock, Craig, Merchant, Akil A., Brennan, Sarah, Jones, Evan, McGovern, Karen, Watkins, D. Neil, Sakamoto, Kathleen M., Matsui, William
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011010/
https://ncbi.nlm.nih.gov/pubmed/21203400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015262
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