Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

The Sonic Hedgehog (Shh) pathway drives a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers. Small-molecule Shh pathway inhibitors have induced tumor regression in mice and patients with medulloblastoma; however, drug resistance rapidly emerges, in some cases vi...

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Main Authors: Lee, Michelle J., Hatton, Beryl A., Villavicencio, Elisabeth H., Khanna, Paritosh C., Friedman, Seth D., Ditzler, Sally, Pullar, Barbara, Robison, Keith, White, Kerry F., Tunkey, Chris, LeBlanc, Michael, Randolph-Habecker, Julie, Knoblaugh, Sue E., Hansen, Stacey, Richards, Andrew, Wainwright, Brandon J., McGovern, Karen, Olson, James M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356655/
https://ncbi.nlm.nih.gov/pubmed/22550175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114718109
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