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Notch signaling is not essential in sonic hedgehog-activated medulloblastoma
Dysregulated signal transduction via the notch pathway has been noted in human and mouse medulloblastoma studies. Gamma secretase inhibitors impair notch signaling by preventing the cleavage of transmembrane notch proteins into their active intracellular domain fragments. Previous studies have demon...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896441/ https://ncbi.nlm.nih.gov/pubmed/20440271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.142 |
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