Germline Elongator mutations in sonic hedgehog medulloblastoma

Cancer genomics has illuminated a wide spectrum of genes and core molecular processes contributing to human malignancy. Still, the genetic and molecular basis of many cancers remains only partially explained. Genetic predisposition accounts for 5-10% of cancer diagnoses(1,2) and genetic events coope...

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Publicado no:Nature
Main Authors: Waszak, Sebastian M., Robinson, Giles W., Gudenas, Brian L., Smith, Kyle S., Forget, Antoine, Kojic, Marija, Garcia-Lopez, Jesus, Hadley, Jennifer, Hamilton, Kayla V., Indersie, Emilie, Buchhalter, Ivo, Kerssemakers, Jules, Jäger, Natalie, Sharma, Tanvi, Rausch, Tobias, Kool, Marcel, Sturm, Dominik, Jones, David T.W., Vasilyeva, Aksana, Tatevossian, Ruth, Neale, Geoffrey, Lombard, Bérangère, Loew, Damarys, Nakitandwe, Joy, Rusch, Michael, Bowers, Daniel, Bendel, Anne, Partap, Sonia, Chintagumpala, Murali, Crawford, John, Gottardo, Nicholas, Smith, Amy, Dufour, Christelle, Rutkowski, Stefan, Eggen, Tone, Wesenberg, Finn, Kjaerheim, Kristina, Feychting, Maria, Lannering, Birgitta, Schüz, Joachim, Andersen, Tina V., Röösli, Martin, Kuehni, Claudia, Grotzer, Michael, Remke, Marc, Puget, Stéphanie, Pajtler, Kristian W., Milde, Till, Witt, Olaf, Ryzhova, Marina, Korshunov, Andrey, Orr, Brent A., Ellison, David W., Brugieres, Laurence, Lichter, Peter, Nichols, Kim E., Gajjar, Amar, Wainwright, Brandon J., Ayrault, Olivier, Korbel, Jan O., Northcott, Paul A., Pfister, Stefan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430762/
https://ncbi.nlm.nih.gov/pubmed/32296180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2164-5
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