Notch signaling is not essential in sonic hedgehog-activated medulloblastoma

Dysregulated signal transduction via the notch pathway has been noted in human and mouse medulloblastoma studies. Gamma secretase inhibitors impair notch signaling by preventing the cleavage of transmembrane notch proteins into their active intracellular domain fragments. Previous studies have demon...

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Main Authors: Hatton, BA, Villavicencio, EH, Pritchard, J, LeBlanc, M, Hansen, S, Ulrich, M, Ditzler, S, Pullar, B, Stroud, MR, Olson, JM
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896441/
https://ncbi.nlm.nih.gov/pubmed/20440271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.142
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