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Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
Hedgehog (Hh) signaling promotes tumorigenesis. The accumulation of a membrane protein Smoothened (Smo) within the primary cilium (PC) is a key event in Hh signal transduction and many pharmacological inhibitors identified to date target Smo’s actions. Smo ciliary translocation is inhibited by some...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905677/ https://ncbi.nlm.nih.gov/pubmed/22554036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300028a |
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