Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity

The Hedgehog signaling pathway is linked to a variety of diseases, notably a range of cancers. The first generation of drug screens identified Smoothened (Smo), a membrane protein essential for signaling, as an attractive drug target. Smo localizes to the primary cilium upon pathway activation, and...

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Autori principali: Wang, Yu, Davidow, Lance, Arvanites, Anthony C., Blanchard, Joel, Lam, Kelvin, Xu, Ke, Oza, Vatsal, Yoo, Jin Woo, Ng, Jessica M.Y., Curran, Tom, Rubin, Lee L., McMahon, Andrew P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724998/
https://ncbi.nlm.nih.gov/pubmed/22921064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.06.012
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