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Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
Smoothened (Smo), a 7-pass transmembrane protein, is essential for transduction of a Hedgehog (Hh) signal across the cell membrane. Smo is also the principle therapeutic target for several candidate drugs in the treatment of Hh-related diseases. Mammalian Smo translocates to the primary cilium in re...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650314/ https://ncbi.nlm.nih.gov/pubmed/19196978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812110106 |
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