Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation

The seven-transmembrane receptor Smoothened (Smo) activates all Hedgehog (Hh) signaling by translocation into the primary cilia (PC), but how this is regulated is not well understood. Here we show that Pitchfork (Pifo) and the G protein-coupled receptor associated sorting protein 2 (Gprasp2) are ess...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Jung, Bomi, Padula, Daniela, Burtscher, Ingo, Landerer, Cedric, Lutter, Dominik, Theis, Fabian, Messias, Ana C., Geerlof, Arie, Sattler, Michael, Kremmer, Elisabeth, Boldt, Karsten, Ueffing, Marius, Lickert, Heiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763541/
https://ncbi.nlm.nih.gov/pubmed/26901434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149477
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