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Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for canc...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4773810/ https://ncbi.nlm.nih.gov/pubmed/26931153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22540 |
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