Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for canc...

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Publicat a:Sci Rep
Autors principals: Jung, Bomi, Messias, Ana C., Schorpp, Kenji, Geerlof, Arie, Schneider, Günter, Saur, Dieter, Hadian, Kamyar, Sattler, Michael, Wanker, Erich E., Hasenöder, Stefan, Lickert, Heiko
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773810/
https://ncbi.nlm.nih.gov/pubmed/26931153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22540
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