The Hedgehog pathway effector Smoothened exhibits signaling competency in the absence of ciliary accumulation

Misactivation of the seven transmembrane protein Smoothened (Smo) is frequently associated with basal cell carcinoma and medulloblastoma. Cellular exposure to secreted Hedgehog (Hh) protein or oncogenic mutations in Hh pathway components induce Smo accumulation in the primary cilium, an antenna-like...

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Publicat a:Chem Biol
Autors principals: Fan, Chih-Wei, Chen, Baozhi, Franco, Irene, Lu, Jianming, Shi, Heping, Wei, Shuguang, Wang, Changguang, Wu, Xiaofeng, Tang, Wei, Roth, Michael G., Williams, Noelle S., Hirsch, Emilio, Chen, Chuo, Lum, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272670/
https://ncbi.nlm.nih.gov/pubmed/25484239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.10.013
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