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Hedgehog chemotaxis is mediated by Smoothened located outside the primary cilium
Regulation of the Hedgehog (Hh) pathway relies on an interaction of two receptors that is not fully understood. Patched1 (Ptch1) binds the Hh ligand, but is also a negative regulator of pathway activity. Binding of Hh ligand to Ptch1 leads to the relocation of the activating receptor Smoothened (Smo...
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| Veröffentlicht in: | Sci Signal |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4557959/ https://ncbi.nlm.nih.gov/pubmed/22912493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002798 |
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