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Hedgehog chemotaxis is mediated by Smoothened located outside the primary cilium

Regulation of the Hedgehog (Hh) pathway relies on an interaction of two receptors that is not fully understood. Patched1 (Ptch1) binds the Hh ligand, but is also a negative regulator of pathway activity. Binding of Hh ligand to Ptch1 leads to the relocation of the activating receptor Smoothened (Smo...

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Vydáno v:Sci Signal
Hlavní autoři: Bijlsma, Maarten F., Damhofer, Helene, Roelink, Henk
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557959/
https://ncbi.nlm.nih.gov/pubmed/22912493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002798
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