Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation

The seven-transmembrane receptor Smoothened (Smo) activates all Hedgehog (Hh) signaling by translocation into the primary cilia (PC), but how this is regulated is not well understood. Here we show that Pitchfork (Pifo) and the G protein-coupled receptor associated sorting protein 2 (Gprasp2) are ess...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Jung, Bomi, Padula, Daniela, Burtscher, Ingo, Landerer, Cedric, Lutter, Dominik, Theis, Fabian, Messias, Ana C., Geerlof, Arie, Sattler, Michael, Kremmer, Elisabeth, Boldt, Karsten, Ueffing, Marius, Lickert, Heiko
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763541/
https://ncbi.nlm.nih.gov/pubmed/26901434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149477
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