Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

[Image: see text] Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in human cervical carcinoma HeLa cell...

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Detalhes bibliográficos
Main Authors: Fass, Daniel M., Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A., Klein, Peter S., Mazitschek, Ralph, Maglathlin, Rebecca L., Lewis, Timothy A., Haggarty, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161516/
https://ncbi.nlm.nih.gov/pubmed/21874153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001954
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