Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells

AKT family of serine-threonine kinases functions downstream of phosphatidylinositol 3-kinase (PI3K) to transmit signals by direct phosphorylation of a number of targets, including the mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and β-catenin. AKT binds to phosphatidylin...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Iaconelli, Jonathan, Lalonde, Jasmin, Watmuff, Bradley, Liu, Bangyan, Mazitschek, Ralph, Haggarty, Stephen J., Karmacharya, Rakesh
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747705/
https://ncbi.nlm.nih.gov/pubmed/28628306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01014
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