Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp(3))–H Arylation

[Image: see text] The development of new antimalarial therapeutics is necessary to address the increasing resistance to current drugs. Bicyclic azetidines targeting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new class of antimalarials, especially due to their activitie...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Maetani, Micah, Zoller, Jochen, Melillo, Bruno, Verho, Oscar, Kato, Nobutaka, Pu, Jun, Comer, Eamon, Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561537/
https://ncbi.nlm.nih.gov/pubmed/28732448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06994
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