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Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds

Target- and phenotype-agnostic assessments of biological activity have emerged as viable strategies for prioritizing scaffolds, structural features, and synthetic pathways in screening sets, with the goal of increasing performance diversity. Here, we describe the synthesis of a small library of func...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Melillo, Bruno, Zoller, Jochen, Hua, Bruce K., Verho, Oscar, Borghs, Jannik C., Nelson, Shawn D., Maetani, Micah, Wawer, Mathias J., Clemons, Paul A., Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644712/
https://ncbi.nlm.nih.gov/pubmed/30133283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b07319
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