Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

[Image: see text] Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of malaria. We recently reported the identification of novel compounds derived from diversity-oriented synthesis with activit...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Maetani, Micah, Kato, Nobutaka, Jabor, Valquiria A. P., Calil, Felipe A., Nonato, Maria Cristina, Scherer, Christina A., Schreiber, Stuart L.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392761/
https://ncbi.nlm.nih.gov/pubmed/28435533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00030
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