Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

[Image: see text] Malaria kills nearly 0.5 million people yearly and impacts the lives of those living in over 90 countries where it is endemic. The current treatment programs are threatened by increasing drug resistance. Dihydroorotate dehydrogenase (DHODH) is now clinically validated as a target f...

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Bibliografski detalji
Izdano u:ACS Omega
Glavni autori: Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N., Palmer, Michael J., Charman, Susan A., Rathod, Pradipsinh K., Phillips, Margaret A.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120730/
https://ncbi.nlm.nih.gov/pubmed/30197997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01573
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