Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

[Image: see text] Malaria kills nearly 0.5 million people yearly and impacts the lives of those living in over 90 countries where it is endemic. The current treatment programs are threatened by increasing drug resistance. Dihydroorotate dehydrogenase (DHODH) is now clinically validated as a target f...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N., Palmer, Michael J., Charman, Susan A., Rathod, Pradipsinh K., Phillips, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120730/
https://ncbi.nlm.nih.gov/pubmed/30197997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01573
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