Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents

[Image: see text] Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity relationships that focused on both a...

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Detalhes bibliográficos
Main Authors: Comer, Eamon, Beaudoin, Jennifer A., Kato, Nobutaka, Fitzgerald, Mark E., Heidebrecht, Richard W., Lee, Maurice duPont, Masi, Daniela, Mercier, Marion, Mulrooney, Carol, Muncipinto, Giovanni, Rowley, Ann, Crespo-Llado, Keila, Serrano, Adelfa E., Lukens, Amanda K., Wiegand, Roger C., Wirth, Dyann F., Palmer, Michelle A., Foley, Michael A., Munoz, Benito, Scherer, Christina A., Duvall, Jeremy R., Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207553/
https://ncbi.nlm.nih.gov/pubmed/25211597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500994n
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