Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from the Nat...

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Autores principales: Weïwer, Michel, Bittker, Joshua A., Lewis, Timothy A., Shimada, Kenichi, Yang, Wan Seok, MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Stockwell, Brent R., Schreiber, Stuart L., Munoz, Benito
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528973/
https://ncbi.nlm.nih.gov/pubmed/22297109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.047
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