Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

A high-throughput screen (HTS) of the MLPCN library using a homogenous fluorescence polarization assay identified a small molecule as a first-in-class direct inhibitor of Keap1-Nrf2 protein-protein interaction. The HTS hit has three chiral centers; a combination of flash and chiral chromatographic s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hu, Longqin, Magesh, Sadagopan, Chen, Lin, Wang, Lili, Lewis, Timothy A., Chen, Yu, Khodier, Carol, Inoyama, Daigo, Beamer, Lesa J., Emge, Thomas J., Shen, Jian, Kerrigan, John E., Kong, Ah-Ng Tony, Dandapani, Sivaraman, Palmer, Michelle, Schreiber, Stuart L., Munoz, Benito
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648997/
https://ncbi.nlm.nih.gov/pubmed/23562243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.013
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados