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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif. The N...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1538563/ https://ncbi.nlm.nih.gov/pubmed/16888629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601243 |
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