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PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
Eukaryote cells balance production of reactive oxygen species (ROS) with levels of anti-oxidant enzyme activity to maintain cellular redox homeostasis. Mitochondria are a major source of ROS, while many anti-oxidant genes are regulated by the Nrf2 transcription factor. Keap1, a redox-regulated subst...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409987/ https://ncbi.nlm.nih.gov/pubmed/18387606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2008.02.014 |
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