Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains cellular redox homeostasis. Keap1, a BTB-Kelch protein, is the major upstream regulator of Nrf2 and controls both the subcellular localization and steady-state levels of Nrf2. In thi...

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Detalhes bibliográficos
Main Authors: Zhang, Donna D., Lo, Shih-Ching, Cross, Janet V., Templeton, Dennis J., Hannink, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC533977/
https://ncbi.nlm.nih.gov/pubmed/15572695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10941-10953.2004
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