The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity is opposed by the BTB/POZ domain protein Keap1. Keap1 is proposed to regulate Nrf2 activity strictly through its capacity to inhibit Nrf2 nuclear import. Recent work suggests that...

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Udgivet i:Mol Cell Biol
Main Authors: Cullinan, Sara B., Gordan, John D., Jin, Jianping, Harper, J. Wade, Diehl, J. Alan
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516753/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15367669/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.19.8477-8486.2004
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