The SCF(HOS/β-TRCP)-ROC1 E3 Ubiquitin Ligase Utilizes Two Distinct Domains within CUL1 for Substrate Targeting and Ubiquitin Ligation

We describe a purified ubiquitination system capable of rapidly catalyzing the covalent linkage of polyubiquitin chains onto a model substrate, phosphorylated IκBα. The initial ubiquitin transfer and subsequent polymerization steps of this reaction require the coordinated action of Cdc34 and the SCF...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Wu, Kenneth, Fuchs, Serge Y., Chen, Angus, Tan, Peilin, Gomez, Carlos, Ronai, Ze'ev, Pan, Zhen-Qiang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC85290/
https://ncbi.nlm.nih.gov/pubmed/10648623
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki