The SCF(HOS/β-TRCP)-ROC1 E3 Ubiquitin Ligase Utilizes Two Distinct Domains within CUL1 for Substrate Targeting and Ubiquitin Ligation

We describe a purified ubiquitination system capable of rapidly catalyzing the covalent linkage of polyubiquitin chains onto a model substrate, phosphorylated IκBα. The initial ubiquitin transfer and subsequent polymerization steps of this reaction require the coordinated action of Cdc34 and the SCF...

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Detalhes bibliográficos
Main Authors: Wu, Kenneth, Fuchs, Serge Y., Chen, Angus, Tan, Peilin, Gomez, Carlos, Ronai, Ze'ev, Pan, Zhen-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85290/
https://ncbi.nlm.nih.gov/pubmed/10648623
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