The SCF(HOS/β-TRCP)-ROC1 E3 Ubiquitin Ligase Utilizes Two Distinct Domains within CUL1 for Substrate Targeting and Ubiquitin Ligation

We describe a purified ubiquitination system capable of rapidly catalyzing the covalent linkage of polyubiquitin chains onto a model substrate, phosphorylated IκBα. The initial ubiquitin transfer and subsequent polymerization steps of this reaction require the coordinated action of Cdc34 and the SCF...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Wu, Kenneth, Fuchs, Serge Y., Chen, Angus, Tan, Peilin, Gomez, Carlos, Ronai, Ze'ev, Pan, Zhen-Qiang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2000
Schlagworte:	Gene Expression
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85290/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.4.1382-1393.2000
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