Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Advances in human genetics have dramatically expanded our understanding of complex heritable diseases. Genome-wide association studies have identified an allelic series of CARD9 variants associated with increased risk of or protection from inflammatory bowel disease (IBD). The predisposing variant o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664502/
https://ncbi.nlm.nih.gov/pubmed/29073062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705748114
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