FoxOs are lineage-restricted redundant tumor suppressors and critical regulators of endothelial cell homeostasis

Activated phosphoinositide 3-kinase (PI3K)-AKT signalling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3 and FoxO4, represent one of several effector arms of PI3K-AKT signalling, prompting genet...

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Detalhes bibliográficos
Main Authors: Paik, Ji-Hye, Kollipara, Ramya, Chu, Gerald, Ji, Hongkai, Xiao, Yonghong, Ding, Zhihu, Miao, Lili, Tothova, Zuzana, Horner, James W., Carrasco, Daniel R., Jiang, Shan, Gilliland, D. Gary, Chin, Lynda, Wong, Wing H., Castrillon, Diego H., DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855089/
https://ncbi.nlm.nih.gov/pubmed/17254969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.029
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