FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

The PI3K-AKT-FoxO pathway is integral to lifespan regulation in lower organisms and essential for the stability of long-lived cells in mammals. Here, we report the impact of combined FoxO1, 3 and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem/...

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Auteurs principaux: Paik, Ji-hye, Ding, Zhihu, Narurkar, Rujuta, Ramkissoon, Shakti, Muller, Florian, Kamoun, Walid S., Chae, Sung-Suk, Zheng, Hongwu, Ying, Haoqiang, Mahoney, Jed, Hiller, David, Jiang, Shan, Protppopov, Alexei, Wong, Wing H., Chin, Lynda, Ligon, Keith L., DePinho, Ronald A.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285492/
https://ncbi.nlm.nih.gov/pubmed/19896444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.09.013
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